Sudden Blank / White Page

Sudden Blank / White Page

Hi Guys - really struggling with this issue.

The page loads fine and sits there for an amount of time (5 minutes, 5 hours - unsure) and randomly the whole page will just turn white as if it's being blanked. I thought perhaps this was a Chrome issue at first - but it's happened on FireFox too. 

I's firing off Ajax requests probably once a second (I queue them to stop overloading the server). 

I'm not even sure where to look. Once it blanks - sometimes, it'll just reload all by itself as if it's been forced to refresh. 

Any ideas or ways of diagnosing - I'm doing nothing in my code that I've not done 100x before.
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    • spode