Calling all javascript/ajax expert opinions :)

Calling all javascript/ajax expert opinions :)

I'm curious about the feedback from the jquery javascript/ajax community regarding issues developing what I would call an "all ajax" site. Meaning, a site that basically begins with a document, then all subsequent action takes place through ajax gets and posts.

First note: I'm not concerned about end users that don't have javascript enabled.
Second note: I'm not asking for feedback regarding usability/design.

My question is regarding performance and overhead as the user continues to use the site during a session. While we've been testing for the past 4 months and have seen some increase in overall memory as the session progresses, it seems to me that with some good practices, like removing and disposing of events and objects, that overhead stays reasonable and performance remains responsive.

At the same time, I would appreciate any input from other jQuery teams regarding their experiences. Also, if anyone would like to offer, what method they find best for monitoring the overhead.

Thanks!
Patrick