hi!
this isn't very difficult. you can do it with the following steps:
1.) create a wordpress "homepage.php" file for the xhtml markup. the markup should include divs that represent content for each menu button (radio active metal, iron city rocks, etc.). each menu button can images wrapped by an anchor tag.
2.) create your css layout for this page. in your css, set menu content divs to "display:none" so the information will not show up on page load.
3.) use jquery .hover to respond to a user mouse over event on any menu image/button. within the .hover method, create a function that will find the related content div with a valid jquery selector. once you know which content to show, use .show to display the information in that blue area within your page.
4.) you can add a .click method to send users to any valid url within wordpress.