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This question is very easy to answer for yourself - just try it.

I can give you an answer, because in the last 5-6 weeks I create a web app which should be suitable for mobile browsers and dektop browsers and I can tell you, it works.

Tested with Firefox 3.6., FireFox 4beta, Opera, Google Chrome, Safari. IE9, I have some optical design problems, but the functionality is given. IE9, I have to do some modifications.

But if you want on desktop and mobile browser, you have to do many things with % width's, otherwise you will have problems.

Best Regards.

And here you have the open source project which works with iPad and desktop browsers: http://bit.ly/nVimJK
You can get the source from GitHub and contribute to it if you like: http://bit.ly/nR9QmH